Doctoral Dissertation Defense: An epidemiologic study of lower urinary tract symptoms and central sensitization in men: Investigations of a mechanistic hypothesis

by Angela Senders, ND, MCR

Lower urinary tract symptoms (LUTS) are a constellation of symptoms that make it challenging to void or store urine. LUTS are common in populations worldwide, yet the underlying mechanisms of LUTS are not fully understood. Central sensitization (CS), a heightened neurologic response to sensory stimuli, may play a role in LUTS etiology. Using musculoskeletal pain as a marker of CS, we observed a positive association between pain and LUTS severity and progression among community dwelling men. We also observed a strong positive association between a validated measure of CS-related symptoms and LUTS severity in a clinical sample of men. This body of research demonstrates that CS may contribute to non-painful LUTS in men.

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